Heterologous Production of 4‑<i>O</i>‑Demethylbarbamide, a Marine Cyanobacterial Natural Product

Abstract

Heterologous expression of the barbamide biosynthetic gene cluster, obtained from the marine cyanobacterium <i>Moorea producens</i>, in the terrestrial actinobacterium <i>Streptomyces venezuelae</i>, resulted in the production of a new barbamide congener 4-<i>O</i>-demethylbarbamide, demonstrating the potential of this approach for investigating the assembly and tailoring of complex marine natural products