pH-Programmable DNA Logic
Arrays Powered by Modular
DNAzyme Libraries
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Abstract
Nature performs complex information processing circuits,
such the
programmed transformations of versatile stem cells into targeted functional
cells. Man-made molecular circuits are, however, unable to mimic such
sophisticated biomachineries. To reach these goals, it is essential
to construct programmable modular components that can be triggered
by environmental stimuli to perform different logic circuits. We report
on the unprecedented design of artificial pH-programmable DNA logic
arrays, constructed by modular libraries of Mg<sup>2+</sup>- and UO<sub>2</sub><sup>2+</sup>-dependent DNAzyme subunits and their substrates.
By the appropriate modular design of the DNA computation units, pH-programmable
logic arrays of various complexities are realized, and the arrays
can be erased, reused, and/or reprogrammed. Such systems may be implemented
in the near future for nanomedical applications by pH-controlled regulation
of cellular functions or may be used to control biotransformations
stimulated by bacteria