Substituted Imidazo[1,2‑<i>a</i>]pyridines as β‑Strand Peptidomimetics

Abstract

New conformationally extended dipeptide surrogates based on an imidazo[1,2-<i>a</i>]pyridine scaffold are described. Efficient synthesis and incorporation into host peptides affords structures with native side-chain functionality and hydrogen bonding elements on one face of the backbone. Structural analysis by NMR suggests that model peptidomimetics adopt a β-strand-like conformation in solution