An Efficient Total Synthesis of (−)-Epothilone B

Abstract

An efficient total synthesis of (−)-epothilone B has been achieved in ca. 8% yield over 11 steps from <b>9</b> (or 10 steps from <b>7</b>/<b>8</b>), which features a bissiloxane-tethered ring closing metathesis reaction to approach the trisubstituted (<i>Z</i>) double bond and forms a new basis for further development of an industrial process for epothilone B and ixabepilone