Nanostructure-Mediated
Transport of Biologics across
Epithelial Tissue: Enhancing Permeability via Nanotopography
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Abstract
Herein, we demonstrate that nanotopographical cues can
be utilized
to enable biologics >66 kDa to be transported across epithelial
monolayers.
When placed in contact with epithelial monolayers, nanostructured
thin films loosen the epithelial barrier and allow for significantly
increased transport of FITC-albumin, FITC-IgG, and a model therapeutic,
etanercept. Our work highlights the potential to use drug delivery
systems which incorporate nanotopography to increase the transport
of biologics across epithelial tissue