A Model of Smart G‑Quadruplex
Ligand
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Abstract
An unprecedented strategy to control the quadruplex-
vs duplex-DNA
selectivity of a ligand is reported. We designed a compound whose
structure can rearrange when it interacts with a G-quadruplex, thereby
controlling its affinity. Thus, the first “smart G-quadruplex
ligand” is reported, since this ligand experiences a structural
change in the presence of quadruplexes but not in the presence of
duplexes, ensuring a high level of quadruplex selectivity