Palladium-Catalyzed <i>ortho</i>-CH-Bond Oxygenation of Aromatic Ketones

Abstract

A palladium-catalyzed C_(sp2)–H bond oxygenation reaction is described. This protocol represents the first example of a C–H bond cleavage/C–O bond formation sequence, by employing a ketone moiety as the directing group. With this new catalytic method, a variety of <i>ortho</i>-acylphenols can be easily accessed from arylketones