Synergistic effect between the nuclear, mitochondrial and membrane transport pathways to counteract DOXO cytotoxicity.

Abstract

<p>Genetic interaction between the genes encoding membrane transporters (<i>Δrav1</i> and <i>Δpmd1</i>) and (A) HR (<i>Δrhp55</i>), (B) Ino80 (<i>Δiec1</i>), and DASH subunits (<i>Δdad3</i> or <i>Δdad5</i>). Genetic interaction between mitochondrial coenzyme Q biosynthesis enzyme <i>(Δcoq2</i>) and (C) HR (<i>Δrhp55</i>), and (D) DASH subunit (<i>Δdad3</i>). All of the mutant pairs showed prominent synthetic growth defect, except <i>Δrhp55Δrav1</i> of which the synthetic growth defect was weak and masked by the strong drug-independent growth defect of the DM.</p