Cytotoxicity of wild-type and <i>Δrav1</i> cells to concentrations of DOXO ranging from 0 to 300

Abstract

<p> <b>µg/ml.</b> Exponentially-growing cells were treated with the indicated level of DOXO for 4 hours. Cell viability was estimated by the number of colonies that was formed after seven day incubation from 200 cells plated on rich media without drug, and expressed as a proportion to the untreated sample. Wild-type cells did not show decrease in viability over the range tested, while <i>Δrav1</i> showed >50% loss in viability at 75 µg/ml.</p