Cycloaromatization Approach
to Polysubstituted Indolizines
from 2‑Acetylpyrroles: Decoration of the Pyridine Unit
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Abstract
A new synthetic route to indolizines with various substituents
on the pyridine moiety was developed by utilizing a facile cycloaromatization
of 2-acetylpyrrole derivatives. Without isolation, the resulting intermediates
were allowed to react with various electrophiles to afford a range
of indolizines. In particular, Suzuki–Miyaura cross-coupling
of <i>O</i>-triflates with (hetero)arylboronic acids permitted
introduction of diverse substituents at the C8 position of an indolizine
skeleton
