Selective Diagnosis of
Diabetes Using Pt-Functionalized
WO<sub>3</sub> Hemitube Networks As a Sensing Layer of Acetone in
Exhaled Breath
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Abstract
Thin-walled WO<sub>3</sub> hemitubes and catalytic Pt-functionalized
WO<sub>3</sub> hemitubes were synthesized via a polymeric fiber-templating
route and used as exhaled breath sensing layers for potential diagnosis
of halitosis and diabetes through the detection of H<sub>2</sub>S
and CH<sub>3</sub>COCH<sub>3</sub>, respectively. Pt-functionalized
WO<sub>3</sub> hemitubes with wall thickness of 60 nm exhibited superior
acetone sensitivity (<i>R</i><sub>air</sub>/<i>R</i><sub>gas</sub> = 4.11 at 2 ppm) with negligible H<sub>2</sub>S response,
and pristine WO<sub>3</sub> hemitubes showed a 4.90-fold sensitivity
toward H<sub>2</sub>S with minimal acetone-sensing characteristics.
The detection limit (<i>R</i><sub>air</sub>/<i>R</i><sub>gas</sub>) of the fabricated sensors with Pt-functionalized
WO<sub>3</sub> hemitubes was 1.31 for acetone of 120 ppb, and pristine
WO<sub>3</sub> hemitubes showed a gas response of 1.23 at 120 ppb
of H<sub>2</sub>S. Long-term stability tests revealed that the remarkable
selectivity has been maintained after aging for 7 months in air. The
superior cross-sensitivity and response to H<sub>2</sub>S and acetone
gas offer a potential platform for application in diabetes and halitosis
diagnosis
