Nanoclustered Gold Honeycombs
for Surface-Enhanced
Raman Scattering
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Abstract
A honeycomb-shaped gold substrate was developed for surface-enhanced
Raman imaging (SERI). The honeycombs are composed of clusters of 50β70
nm gold nanoparticles and exhibit high Raman enhancement efficiency.
An average surface enhancement factor (ASEF) of 1.7 Γ 10<sup>6</sup> was estimated for a monolayer of l-cysteine molecules
adsorbed to gold via a thiol linkage. The presence of a linear relationship
in the low concentration region was observed in SERI detection of
malachite green isothiocyanate (MGITC). These results together with
the high reproducibility and simple and cost-effective fabrication
of this substrate suggest that it has utility for applications of
surface-enhanced Raman scattering (SERS) in quantitative diagnoses
and analyte detection