<p>a) GSEA identifies methylation changes of mouse adenoma in human colon cancer. Gene signatures comprise genes with promoter hypo- or hypermethylation in mouse adenoma (see also <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003250#pgen-1003250-g004" target="_blank">Figure 4a</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003250#pgen.1003250.s013" target="_blank">Table S5</a>), genes were ordered by directional methylation changes in human colon cancer (normal tissue versus carcinoma). Mouse and human gene homologues were matched using ENSEMBL Biomart (approx. 14300 unique orthologue pairs were identified). b) Promoter hypo- and hypermethlyation is conserved between mouse APC<sup>Min</sup> adenoma and human colon cancer. Genes were selected from those that are significantly hyper- or hypomethylated in APC<sup>Min</sup> adenoma. Conserved genes were identified as the core enrichment group of GSEA analysis in a). Figure shows top eleven hypo- and hypermethylated genes in human colon cancer. blue: low relative methylation; red: high relative methylation.</p
