<p>These diagrams show that by alternating the antibiotics cefepime, ceftazidime, and cefprozil susceptibility to those antibiotics can be restored in bacterial populations expressing variant alleles present in TEM-50 adaptive landscapes. 2a. (Top left) The TEM-50 adaptive landscape in cefepime. Yellow peaks indicate the adjacent alleles that are important during cefepime selection. 2b. (Top right) The TEM-50 adaptive landscape in ceftazidime. Orange peaks indicate the adjacent alleles that are important during ceftazidime selection. 2c. (Bottom left) The TEM-50 adaptive landscape in cefprozil. Red peaks indicate the adjacent alleles that are important during cefprozil selection. 2d. (Bottom right) Composite cycle: The yellow arrow indicates the direction of selection in the presence of cefepime. The red arrows indicate the direction of selection in the presence of cefprozil. The orange arrow indicates the direction of selection in the presence of ceftazidime. Rotation of these antibiotics results in cyclical renewal of antibiotic susceptibility.</p
