Hypochlorous Acid Turn-on Fluorescent Probe Based on Oxidation of Diphenyl Selenide

Abstract

A BODIPY-based fluorescent probe, <b>HCSe</b>, has been successfully developed for the rapid detection of hypochlorous acid based on the specific HOCl-promoted oxidation of diphenyl selenide in response to the amount of HOCl. Confocal fluorescence microscopy imaging using RAW264.7 cells showed that the new probe <b>HCSe</b> could be used as an effective fluorescent probe for detecting HOCl in living cells