GW4064 treatment inhibited the upregulation of ET-1 expression during HSC activation.

Abstract

<p>Freshly isolated rat HSCs were cultured for 7 days in 10% FCS alone (control) or 10% FCS medium containing 1 µmol/L GW4064. The mRNA expression levels of ET-1 (A), ETB (B) and ETA (C) were examined by real-time RT-PCR, respectively. Data are mean ±SE of 6 experiments. *<i>P</i><.001 vs. control cells.</p