Abstract

<p>(<b>A</b>) N100 amplitude reduction during 1 Hz-rTMS (group mean values). The TMS artifact (black box) has been cut out. Each curve represents an average of 100 trials (1–100, 101–200, …, 801–900). Electrodes C3, CP3’ and CP5’ were pooled. <i>Left</i>: TMS-evoked N100 amplitude continuously decreased during the stimuli 1–500. <i>Right</i>: N100 amplitude reached a plateau and was not further reduced by continued stimulation (pulses 500–900). (<b>B</b>) Single patient example. (<b>C</b>) TMS-evoked N100 amplitude was reduced during 1 Hz-rTMS regardless of the order of 1 Hz-rTMS vs. sham stimulation (blue: first 1 Hz-rTMS, second sham stimulation; red: first sham stimulation, second 1 Hz-rTMS; vertical bars show 0.95 confidence intervals). (<b>D</b>) Voltage and current source density (CSD) maps (blue areas indicate negativity, red areas positivity) show an N100 maximum above the stimulated left left central area and an intensity reduction during 1 Hz-rTMS. <i>Left</i>: N100 during stimuli 1–100. <i>Right</i>: N100 during stimuli 801–900.</p

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