Association of Hepatitis B and C viremia and Hepatitis C genotype with progressive kidney disease.

Abstract

<p>Final models were adjusted for trial, age, race, infection through same sex exposure, prior AIDS diagnosis, CD4, CD4 nadir, previous exposure to antiretrovirals, previous exposure to indinavir, treatment with antihypertensives, treatment with lipid lowering therapy, estimated glomerular filtration rate, and year of randomization, all measured at randomization into the parent trial. As appropriate, analyses were also adjusted for ¹Hepatitis C (HCV) antibody status or ² Hepatitis B surface antigen (HBsAg) status. Participants with positive HBsAg were further stratified by the presence or absence of detectable HBV DNA, with a cutoff of <357 IU/ml. The number of patients (events) for HBsAg negative, positive with HBV DNA <357 IU/mL, and positive with HBV DNA ≥357 IU/ml were 3321 (113), 44 (6), and 70 (8), respectively. Participants with positive HCV antibody were further stratified into those with undetectable HCV RNA, low HCV RNA (≤800,000 IU/ml), and high HCV RNA (>800,000 IU/ml). The number of patients (events) for HCV antibody negative, positive with undetectable HCV RNA, low HCV RNA, and high HCV RNA were 2963 (102), 108 (4), 212 (9), and 151 (12), respectively. The analysis of HCV genotype was limited to participants with positive HCV antibody and known HCV genotype, stratified as genotype 1 (258 patients, 18 events) or other (95 patients, 3 events).</p