<p><b>A</b>–<b>B</b>. Whole-cell patch clamp recordings of odorant- and VUAA1-induced currents in AgOr-expressing cells (n = 3). <b>A.</b> VU0183254 (100 µM) decreased responses to delta-undecalactone (1 µM) and VUAA1 (100 µM) in HEK cells expressing AgOrco+AgOr48. <b>B.</b> Responses to eugenol (1 µM) and VUAA1 (100 µM) in AgOrco+AgOr65 cells were reduced by VU0183254 (100 µM). <b>C</b>–<b>D</b>. Cells expressing Orco from either <i>An. gambiae</i> (<b>C</b>) or <i>Harpegnathos saltator</i> (<b>D</b>) had reduced VUAA1 (100 µM) currents in the presence of 100 µM VU0183254. <b>E.</b> Capsaicin (10 µM) currents in HEK cells expressing rat TRPVI were not reduced with by 100 µM VU0183254. Holding potential for all figures is −60 mV.</p
