Model of the predicted secondary structure of PiPV-B IRES.

Abstract

<p>Domains are labelled II and III, stem-loops are labelled IIId, IIIe etc. Stem 1 and stem 2 are elements of the pseudoknot. The underlined AUG triplet in position 429 is the first AUG codon after the pseudoknot. Shaded rectangles indicate bases in domain III that are conserved in the IRES type IV elements. The predicted secondary structure upstream of stem-loop IIId (the sequence between nucleotide 125 and 329) is not shown. The structure was predicted using Mfold.</p

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