Effects of cysteamine in chronic corticosterone-treated mice in the Open Field test.

Abstract

<p>CD-1 male mice were treated for 7 weeks with vehicle (0.45% hydroxypropyl-β-cyclodextrin) or corticosterone (CORT; 35 ug/ml) in the presence or absence of cysteamine (CYS; 150 mg/kg/day) during the last three weeks of the corticosterone treatment. (A) Mean total of the time-spent in the center for the entire session, (B) the ambulatory counts for each 5 min period, (C) the total ambulatory distance and (D) the ambulatory distance in the center over total. Values plotted are mean ± SEM (n = 8–10 per group). Bonferroni's post hoc test. *p<0.05 versus vehicle and <sup>#</sup>p<0.05 versus CORT.</p

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