CTLA-4 blockade enhances the proliferative capacity of CD4⁺ and CD8⁺ T cells.

Abstract

<p>Fresh PBMCs isolated after the second immunization were stained with CFSE and stimulated with SIVgag, env, and pol peptides <i>in vitro</i> for 5 days to determine the proliferative capacity of antigen-specific cells. The proliferative capacity of the CD4⁺(<b>a</b>) and CD8⁺ (<b>b</b>) T cell compartments are shown as stacked group mean responses ± SEM. Statistical differences between groups were determined by a one-way ANOVA with a Tukey post-hoc test.</p