Post-injury administration of SB-216763 improves motor function.

Abstract

<p><b>A</b>) Schematic of the drug injection and behavioral testing paradigm. Rats (n = 10/group) were injected (i.p.) for the first 5 days post-injury with either 5.0 mg/kg SB-216763 or vehicle. SB-216763-treated rats had <b>B</b>) comparable vestibulomotor deficits, but made significantly fewer <b>C</b>) ipsilateral and <b>D</b>) contralateral foot faults. <b>E</b>) Body weight was unaffected by SB-216763 administration. Data are presented as the mean ± SEM. ‡, P<0.05 by two-way repeated measures ANOVA.</p