The RsW50 of regulatory spleen cells is decreased by enriching for CD8⁺ regulatory spleen cells.

Abstract

<p>The footpads of mice immunized with TNP-BSA and CFA 9 days previously received id CD8⁺ cells or unseparated AC-SPL cells prepared as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0022496#pone-0022496-g001" target="_blank">Fig. 1</a> immediately after the footpad was challenged with epicutaneous PCl. Swelling was measured 24 hr later. The data is pooled from two separate experiments with six mice /group. NAÏVE: non-immunized mice, IMM: immunized mice that did not receive regulatory spleen cells, CD8⁺: immunized mice that received CD8⁺ regulatory spleen cells. p<0.01. Straight lines were generated by curve fit software.</p