Resistance induces internucleosomal DNA fragmentation in FOA-resistant parasite grown in mice without drug.

Abstract

<p>Polyacrylamide gel electrophoretic fraction of DNA was done in two independent experiments, A and B. In A, lanes 1 represent DNA extracted from the wild-type parasite that shows no cleavage, while lanes 2 represent cleaved DNA of FOA-resistant parasite, with the main band at ≈200 bp. Similar results are represented in B, where the wild-type shows no cleaved DNA (lanes 1), while FOA-resistant parasite shows cleaved DNA and a clear band at ≈200 bp (lanes 2). Lane M is the molecular size marker (pSG5/Hinf I and φX174/HincII for A, and pSG5/Hinf I for B).</p

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