<p>MDA-MB-435S cells were implanted in the mammary fat pad of SCID/NOD mice. Two days post-implantation, the mice were divided into 3 groups (one group of 10 control siRNA-injected mice and two groups of 5 targeted siRNA mice) and the groups received twice weekly injections of either control, Src+STAT3, or Src+STAT3+Myc siRNA into the site of the cell implantation/tumor. 47 days post-implantation, 5 mice in the control group were switched to Src+STAT3 siRNA injections for the remainder of the experiment (Control, then Src+STAT3 group). Tumor growth was monitored and the results are shown (<b>A</b>), with each treatment group shown in a single panel, and individual mouse tumors represented by connected data points. 126 days post-implantation, the primary tumor(s) were excised (<b>B</b>) and weighed. The tumor weights for each mouse (data points) and the average tumor weight for each group (horizontal bar) is shown (<b>C</b>). Tumor weight data was analyzed by Analysis of Variance and Tukey's pairwise comparison, with significant differences between the control group and two of the treatment groups noted ( *p<0.05).</p
