In the two last centuries many socio-demographic variables (such as mortality, fertility and remarriage) in Sardinia have shown a quite singular pattern, if compared to those observed for the rest of Italy. In this work the analysis of these phenomena is carried out both at micro and macro level, taking into account their effects on social and economic context. Based on the rich set of individual data referring to the community of Alghero, the micro approach aims to explain how demographic, cultural, environmental and economic factors influenced stillbirth and infant mortality rates as well as propensity to remarriage for the years 1866-1925. In order to highlight territorial differentials still present in Sardinia, the macro approach focuses on the estimation of municipal indicators of fertility and mortality in the second half of 20th century. From this starting point, a forecast of the population and the main demographic indicators of the Sardinian municipalities is proposed