Identified T-cell epitopes in wheat gluten and their observed T-cell response in celiac disease patients.

Abstract

<p>Glutamine residues expected to be targeted by TG2 are given in bold.</p>a<p>Peptide PQPQLPYPQPQLPY harboring both epitopes, DQ2-α-II and DQ2-α-III, was tested.</p>b<p>Peptide LQPQQPFPQQPQQPYPQQPQ harboring both epitopes, DQ2-γ-III/DQ8-γ-I and DQ2-γ-VI, was tested.</p>c<p>Note that this peptide is not identical to peptide QQPPFSQQQQQPLPQ which was previously known as the “Glt-17” epitope. Peptide QQPPFSQQQQQPLPQ has previously been tested for T-cell response in CD patients: 3/20 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0014056#pone.0014056-Vader2" target="_blank">[17]</a>.</p><p>♦Identified TG2 peptide substrates that harbor incomplete 9mer core binding regions.</p