No difference in disease incubation period is observed in Tga20 chimeric mice inoculated with limiting doses of the RML strain (10<sup>−7</sup> LogLD50).
<p>Tga20 mice were lethally irradiated, reconstituted with femoral bone marrow cells from B6 (square), Tga20 (triangle) or Prp<sup>0/0</sup> (circle) mice and inoculated with the RML prion scrapie strains. The incubation periods are expressed as days post-inoculation (DPI). At this low dose, only 7/10 mice developed scrapie. A <i>P</i> value of 0.19 was obtained using the Kruskal-Wallis ANOVA test when comparing the three groups of mice.</p
