Non-syndromic hearing loss is the most common
sensory disorder in humans; 15%–20% of cases are
transmitted as a dominant trait (NSDA) with 40 loci having
been mapped and 16 genes having been identified. Here,
we report the mapping of a novel NSDA locus, DFNA48,
to chromosome 12q13-q14 in a large multigenerational
Italian family. A maximum lod score of 3.31 was obtained
with marker D12S83, whereas markers D12S347 and
D12S1703 defined a region of approximately 18 cM. Positional
candidate genes are being screened for deafnesscausing
mutations