Synthesis of <i>N</i>-[4-(propyl)cyclohexyl]-amides with anti-inflammatory and analgesic activities

Abstract

Seventeen (un)substituted N-[4-(propyl)cyclohexyl]-amides (6a–h, 7a–h and 8) were synthesized and tested as anti-inflammatory and analgesic agents. The substituents on the aromatic ring were chosen in order to study the influence of electron-withdrawing or electron-donating residues, that change the electronic density on the aromatic moiety. The pharmacological results allow drawing some preliminary considerations on structure–activity relationships