Enantioselective synthesis of (<i>S</i>)- and (<i>R</i>)-tolterodine by asymmetric hydrogenation of a coumarin derivative obtained by a Heck reaction

Abstract

An efficient and short enantioselective synthesis of (S)- and (R)-tolterodine was performed by asymmetric hydrogenation of a coumarin intermediate, easily obtained by a Heck reaction from inexpensive and commercially available starting materials