Figure S6. An illustration of miR-375-HOXB3-CDCA3/DNMT3B regulatory circuitry. (A) In normal hematological cells or leukemic cells treated with AZA, miR-375 expression is increased because of DNA hypomethylation. Upregulation of miR-375 inhibits HOXB3 expression, resulting in the arrest of proliferation and reduction of colony formation via decreasing the expression of CDCA3. Moreover, the decreased expression of HOXB3 can not increase and recruit DNMT3B to bind in the pre-miR-375 promoter and maintains the hypomethylation of pre-miR-375, which finally leads to the upregulated expression of miR-375, in turn. (TIFF 592Â kb
