'International Union of Pure and Applied Chemistry (IUPAC)'
Abstract
The development of a novel reaction ideal in terms of atom economy was achieved.
The scope of the reaction was evaluated in the presence of Pd and Pt catalysts. The first
enantioselective Pt-promoted enyne carboalkoxycyclization was developed in up to 85 %
stereoselectivity. This ideal atom-economical reaction afforded the corresponding functionalized
five-membered carbo- and heterocycles in good to excellent yields. The use of silver
salts combined with (R)-Ph-BINEPINE, a monophosphane atropisomeric ligand, was found
to be the best-suited combination for moderate to high enantioselectivities on carbonated and
nitrogenated substrates
