Diagram summarizing the tissue-specific imprinting defects of the <i>H19</i>^{<i>hIC1</i>Δ<i>2</i>.<i>2</i>} mice.

Abstract

<p>White rectangles represent the <i>Igf2</i> and <i>H19</i> genes, grey rectangle mIC1 and green rectangles hIC1Δ2.2. Enhancers are indicated by green ovals. Transcription direction is indicated by arrows and transcription intensity by arrow thickness. Lollipops indicate CTS methylation status: filled lollipops, methylated CTSs; open lollipops: non-methylated CTSs; half-filled lollipops: partially methylated CTSs; dashed lollipops: missing CTSs in the deleted region of hIC1Δ2.2. Curved arrows indicate <i>Igf2</i> activation by downstream enhancers: arrow thickness is inversely proportional to the insulator strength inferred from allele-specific <i>Igf2</i> expression in each specific tissue. P: paternal chromosome; M: maternal chromosome.</p