Introduction: Cupper containing amine oxidase (Cu-AO) catalyzes
the deamination of primary amines to corresponding aldehydes
in the presence of oxygen with the subsequent release of ammonia
and hydrogen peroxide. Cu-AO also is known as soluble vascular
adhesion molecule-1 (sVAP-1). It has been shown that the serum
level of Cu-AO changes in various cancers. Literature review showed
that there was no information on Cu-AO serum concentration among
Iranians as well as in gastric cancer patients. The present study was
conducted with two major aims 1) determination of Cu-AO
concentration in healthy people; 2) to investigate the changes of
the enzyme in gastric patients compared to control.
Material and method: This investigation as a case–control study
included 200 healthy and GC patient volunteers referred to Aras
Clinic in Imam Khomeini Hospital. Blood samples were collected and
serum was separated and stored at −70 °C until ELISA examinations.
Questionnaires were distributed and filled out by both patients and
healthy people.
Results and conclusion: Present investigation showed that there
is no significant change in serum level of Cu-AO in regard to sex, age,
smoking and BMI. The serum level of Cu-AO in healthy subjects was
higher than values reported in other countries. Whether these finding
would open new sights into etiology of high incidence of GC in
Ardabil province needs further investigations. Cu-AO levels in serum
show a significant decrease in GC patients in relative to controls, this
decline in Cu-AO might have been used as a biomarker for gastric
cancer diagnosis
