Background and aims: Anemia and increased
inflammation are the main causes of mortality in
chronic kidney disease (CKD) patients. This study
was designed to explore the probable relationship
of hemoglobin (Hb) with serum haptoglobin (HP),
its genotypes and inflammation statues in CKD
stage 4 patients with anemia.
Methods: The subjects of the study was 40 anemic
CKD patients on stage 4 [GFR = 15 - 29 ml/
min/1.73 m2]. Serum biochemical factors as well
as ferritin, HP and IL-6 levels were measured by
standard methods. Haptoglobin genotypes were
determent by PCR method and the accuracy of genotyping
was confirmed by sequencing amplified
fragments and RFLP analysis.
Results: Results showed that although HP2-2
was the most common genotype (%72.5), no significant
correlations between HP genotypes with
Hb and HP levels were found (p= 0.49, p= 0.32,
respectively). Significant negative correlation
between Hb level with IL-6 and hs-CRP levels (p<
0.001 and p< 0.05, respectively) and a significant
positive correlation between Hb and ferritin levels
was found (p< 0.05).
Conclusion: The results suggest that HP genotype
and serum HP levels have no significant
effect on hemoglobin level in CKD stage 4 patients.
However, Hb level is associated with inflammation
and albumin status
