Table S1. Study outcomes stratified by sex, 95% CI. Table S2. Analysis population sizes and p values from multivariate regression analyses. (DOCX 29 kb

Carl Willers (3910186)

Elisabeth Ekstrand (4920784)

Hélène Pessah-Rasmussen (3910177)

Ingrid Lekander (3910180)

Katharina Sunnerhagen (4920781)

Mia von Euler (3910174)

Mikael Lilja (3116679)

Biology of Sex Differences

Background: Differences in stroke care and health outcomes between men and women are debated. The objective of this study was to explore the relationship between patients' sex and post-stroke health outcomes and received care in a Swedish setting. Methods: Patients with a registered diagnosis of acute intracerebral hemorrhage (ICH) or ischemic stroke (IS) within regional administrative systems (ICD-10 codes I61* or I63*) and the Swedish Stroke Register during 2010-2011 were included and followed for 1 year. Data linkage to multiple other data sources on individual level was performed. Adjustments were performed for age, socioeconomic factors, living arrangements, ADL dependency, and stroke severity in multivariate regression analyses of health outcomes and received care. Health outcomes (e.g., survival, functioning, satisfaction) and received care measures (regional and municipal resources and processes) were studied. Results: Study population: 13,775 women and 13,916 men. After case-mix adjustments for the above factors, we found women to have higher 1-year survival rates after both IS (ORfemale = 1.17, p &lt; 0.001) and ICH (ORfemale = 1.65, p &lt; 0.001). Initial inpatient stay at hospital was, however, shorter for women βfemale, IS = -0.05, p &lt; 0.001; βfemale, ICH = -0.08, p &lt; 0.005). For IS, good function (mRS &lt;= 2) was more common in men (ORfemale = 0.86, p &lt; 0.001) who also received more inpatient care during the first year βfemale = -0.05, p &lt; 0.001). Conclusions: A lower proportion of women had good functioning, a difference that remained in IS after adjustments for age, socioeconomic factors, living arrangements, ADL dependency, and stroke severity. The amount of received hospital care was lower for women after adjustments. Whether shorter hospital stay results in lower function or is a consequence of lower function cannot be elucidated. One-year survival was higher in men when no adjustments were made but lower after adjustments. This likely reflects that women were older at time of stroke, had more severe strokes, and more disability pre-stroke-factors that make a direct comparison between the sexes intricate

Willers, Carl

Lekander, Ingrid

Ekstrand, Elisabeth

Lilja, Mikael

Pessah-Rasmussen, Hélène

Sunnerhagen, Katharina S.

von Euler, Mia

Publikationer från Umeå universitet

Sex as predictor for achieved health outcomes and received care in ischemic stroke and intracerebral hemorrhage : a register-based study

Background: Differences in stroke care and health outcomes between men and women are debated. The objective of this study was to explore the relationship between patients' sex and post-stroke health outcomes and received care in a Swedish setting. Methods: Patients with a registered diagnosis of acute intracerebral hemorrhage (ICH) or ischemic stroke (IS) within regional administrative systems (ICD-10 codes I61∗or I63∗) and the Swedish Stroke Register during 2010-2011 were included and followed for 1 year. Data linkage to multiple other data sources on individual level was performed. Adjustments were performed for age, socioeconomic factors, living arrangements, ADL dependency, and stroke severity in multivariate regression analyses of health outcomes and received care. Health outcomes (e.g., survival, functioning, satisfaction) and received care measures (regional and municipal resources and processes) were studied. Results: Study population: 13,775 women and 13,916 men. After case-mix adjustments for the above factors, we found women to have higher 1-year survival rates after both IS (ORfemale = 1.17, p < 0.001) and ICH (ORfemale = 1.65, p < 0.001). Initial inpatient stay at hospital was, however, shorter for women (β female, IS = - 0.05, p < 0.001; β female, ICH = - 0.08, p < 0.005). For IS, good function (mRS ≤ 2) was more common in men (ORfemale = 0.86, p < 0.001) who also received more inpatient care during the first year (β female = - 0.05, p < 0.001). Conclusions: A lower proportion of women had good functioning, a difference that remained in IS after adjustments for age, socioeconomic factors, living arrangements, ADL dependency, and stroke severity. The amount of received hospital care was lower for women after adjustments. Whether shorter hospital stay results in lower function or is a consequence of lower function cannot be elucidated. One-year survival was higher in men when no adjustments were made but lower after adjustments. This likely reflects that women were older at time of stroke, had more severe strokes, and more disability pre-stroke - factors that make a direct comparison between the sexes intricate

Von Euler, Mia

Lund University Publications

Sex as predictor for achieved health outcomes and received care in ischemic stroke and intracerebral hemorrhage : A register-based study

FigShare

Additional file 1: of Sex as predictor for achieved health outcomes and received care in ischemic stroke and intracerebral hemorrhage: a register-based study

Abstract Background Differences in stroke care and health outcomes between men and women are debated. The objective of this study was to explore the relationship between patients’ sex and post-stroke health outcomes and received care in a Swedish setting. Methods Patients with a registered diagnosis of acute intracerebral hemorrhage (ICH) or ischemic stroke (IS) within regional administrative systems (ICD-10 codes I61* or I63*) and the Swedish Stroke Register during 2010–2011 were included and followed for 1 year. Data linkage to multiple other data sources on individual level was performed. Adjustments were performed for age, socioeconomic factors, living arrangements, ADL dependency, and stroke severity in multivariate regression analyses of health outcomes and received care. Health outcomes (e.g., survival, functioning, satisfaction) and received care measures (regional and municipal resources and processes) were studied. Results Study population: 13,775 women and 13,916 men. After case-mix adjustments for the above factors, we found women to have higher 1-year survival rates after both IS (ORfemale = 1.17, p < 0.001) and ICH (ORfemale = 1.65, p < 0.001). Initial inpatient stay at hospital was, however, shorter for women (β female, IS = − 0.05, p < 0.001; β female, ICH = − 0.08, p < 0.005). For IS, good function (mRS ≤ 2) was more common in men (ORfemale = 0.86, p < 0.001) who also received more inpatient care during the first year (β female = − 0.05, p < 0.001). Conclusions A lower proportion of women had good functioning, a difference that remained in IS after adjustments for age, socioeconomic factors, living arrangements, ADL dependency, and stroke severity. The amount of received hospital care was lower for women after adjustments. Whether shorter hospital stay results in lower function or is a consequence of lower function cannot be elucidated. One-year survival was higher in men when no adjustments were made but lower after adjustments. This likely reflects that women were older at time of stroke, had more severe strokes, and more disability pre-stroke—factors that make a direct comparison between the sexes intricate

Carl Willers

Ingrid Lekander

Elisabeth Ekstrand

Mikael Lilja

Hélène Pessah-Rasmussen

Katharina S. Sunnerhagen

Mia von Euler

Directory of Open Access Journals

Sex as predictor for achieved health outcomes and received care in ischemic stroke and intracerebral hemorrhage: a register-based study

Academic Archive On-line (Umeå University, Sweden)

Digitala Vetenskapliga Arkivet - Academic Archive On-line

https://figshare.com/articles/Additional_file_1_of_Sex_as_predictor_for_achieved_health_outcomes_and_received_care_in_ischemic_stroke_and_intracerebral_hemorrhage_a_register-based_study/5960422

Additional file 1: of Sex as predictor for achieved health outcomes and received care in ischemic stroke and intracerebral hemorrhage: a register-based study

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