Several evidences show that oxidative stress is high among patients with hemodialysis. This study was aimed to investigate the oxidative stress and serum level of zinc and copper in patients with non-diabetic hemodialysis. In a case - control study 60 non-diabetic hemodialysis patients referred to hospital hemodialysis 1387 were studied. Lipid profile, glucose, creatinine, urea, total protein, albumin, zinc, copper, malondialdehyde, total antioxidant capacity and superoxide dismutase and glutathione peroxidase enzymes were measured in both groups. The results using the software T test and Pearson correlation coefficient was used to measure the dependence between variables in the SPSS 16 statistical was used. The amount of blood sugar, cholesterol, triglycerides, total protein, albumin Significantly less than the control group. Superoxide dismutase and glutathione peroxidase enzyme activity of red blood cells serum total antioxidant capacity in hemodialysis patients was significantly higher than healthy individuals. Concentrations of the Copper and malondialdehyde in the two groups did not differ significantly.This study shows that in non-diabetic hemodialysis patients, increased activity of antioxidant enzymes prevent oxidative stress is increased. Zinc deficiency was also observed in these patients
