Background: Bacterial vaginosis is characterized by a imbalance in the vaginal ecosystem, this change is due to an overgrowth of anaerobic bacteria and a contaminant decrease in the number of lactobacilli and increase in vaginal pH more that 4.5. Normal vaginal pH is within 3.5 until 4.5. Bacterial Vaginosis is associated with an increased risk for a host of obstetric, gynecological, including pelvic inflammatory disease, postoperative infection following hysterectomy, cervix abnormal cytology and preterm birth. As well as recent media coverage of antibiotic resistance and a growing movement toward 'natural therapies' have led to increasing interested in non-antibiotic treatment for Bacterial Vaginosis. The most proposed non-antibiotic therapies for Bacterial Vaginosis include two categories- probiotic therapies, with aim to provide the bacteria to directly supplement or restore a woman's healthy lactobacillus-dominated flora and acid-restoring therapies such as buffer gel.
Objective: To compare the effective of suppository lactobacillus acidophilus with metronidazol tablet vaginal on vaginal pH, sings and symptoms of Bacterial Vaginosis.
Method: In double-blind, paralleled randomized clinical trial, 300 participants enrolled and 40 patients had inclusion criteria. They are separated randomly in two groups of suppository lactobacilli and metronidazol vaginal tablet. This study was carried on at out-patient private and general gynecology clinics in Tabriz.
Results: There are no significant differences between the metronidazol and lactobacilli groups in vaginal pH decreases (P=0.118), but the cure rate was 100% for metronidazol group and 75% for lactobacilli group.
Conclusion: The based on the results of this research the preventive treatment with Lactobacilli doesn’t better than from metronidazol, but is considered on the same area. However, its advantage is not the need of necessity to take antibiotics for a long period
