Introduction: Hasidism and melasma are common problems in women. Multiple ethiologic factors have some role in their existence. Melasmatic patients in some surveys had higher rate of hirsutism than normal rang of society. In recent studies serum levels of PSA have considered in hirsute women
In this study serum levels of PSA were studied in melasm-Hirsutisim involved women with melasma involved women.
Materials & Methods: In a case-control study 34 melasma hirsute patients and 38 melasma involved patients were studied. According to Ferryman – Galway score, all of melasma – hirsute women had a hirsutism score of 6 or more. Serum samples were prepare in mid – follicular phase of menstrual cycle.
Serum PSA, 17 hydroxy progesterone, Androstenedione and free testosterone were measured. Those concentrations were analyzed by two different assays, Radioimmunoassay and chemiluminescent enzyme immunoassay. Data processing were done by SPSS method.
Results: The mean age of Melasma – Hirsute women and melasma were 30.3±7.2; 31±6.5 years, respectively.
Mean ± SD of Ferryman – Galway score in Melasma - Hirsute group was 13.76 ± 6.1. PSA concentration in two Melasma - Hirsute subjects and Melasma with both assays was under 0.01 ng/ml. Familial incidence of melasma and hirsutism in case group was more than control group. (p=0.01) infertility in case group was more than control group (p=0.05/). 17(OH) progestron range in case group (in81%) and control group (in 35.5%) were higher than normal range (p=0.002).
Conclusion: Serum concentration of PSA by radioimmunoassay and chemiluminescent enzyme immunoassay in melasma – hirsute patients is lower than 0.01 ng/ml, and lower concentrations are not detectable by these assays. However, ultra sensitive assay need for more subtle measurement
