This article reviews a series of scientific articles written by the authors, where the following topics
were investigated in relation to non-unidirectional airflow cleanrooms.
(1) The air supply rate required to obtain a specified concentration of airborne contamination.
(2) The calculation of concentrations of airborne contaminants in different ventilation and dispersion
of contamination situations.
(3) The decay of airborne contamination
(a) during the ‘clean up’ test described in Annex 1 of the EU Guidelines to Good Manufacturing
Practice (2008);
(b) during the recovery rate test described in Annex B12 of ISO 14644-3 (2005);
(c) associated with clean areas, such as airlocks, to reduce airborne contamination before a door
into a cleanroom is opened.
Worked examples are provided to demonstrate the calculation methods to provide solutions to the
above topics
