Bajouco, Miguel

Caldeira, Salomé

Macedo, António

Madeira, Nuno

Martins, Maria João

Mota, David

Oliveira, André

Pereira, Ana Telma

Ribeiro, Joana

Roque, Carolina

Santos, Vítor

Estudo Geral

Methods: Participants were 21 BDD patients, 19 obsessive-compul-
sive disorder (OCD) patients and 21 healthy controls (HC), who
were age-, sex-, and IQ-matched. Stimuli were photographs of par-
ticipants’ own faces as well as those from the Pictures of Facial
Aﬀect battery (Ekman and Friesen, 1975). Outcome measures were
aﬀect recognition accuracy as well as spatial and temporal scan-
path parameters.
Results: The BDD group exhibited significantly decreased recogni-
tion accuracy for their own face relative to the HC group, and this
was most pronounced for those that had a key concern centred on
their face. Individual qualitative scanpath analysis revealed both
restricted as well as extensive scanning behaviours in BDD partici-
pants with a specified facial preoccupation. Persons with severe
BDD also exhibited more marked scanpath deficits relative to
those with less severe BDD.
Conclusions: Future research should be directed at extending the
current work by incorporating neuroimaging techniques, and
investigations of eye-tracking focused on aﬀected body parts in
BDD. These could yield fruitful therapeutic applications via incor-
poration with existing treatment approaches.
P-282
It’s all in the words: lexical processing is
impaired in bipolar mania
S Rossella, T Van Rheenenb
aSwinburne University, Melbourne, Australia, bUniversity of
Melbourne, Melbourne Neuropsychiatry Centre, Melbourne,
Australia
Background and Aims: Verbal learning and memory diﬃculties are
a core cognitive impairment in schizophrenia and bipolar disorder.
Word recognition is a fundamental process that is influential dur-
ing higher order verbal memory tasks. Despite a wealth of litera-
ture on verbal learning and memory deficits we only have a
rudimentary understanding of more basic word recognition or lexi-
cal processing in these disorders. This study sought to investigate
word recognition in bipolar and schizophrenia groups compared to
healthy controls using a lexical decision task. The task manipulated
the frequency and the imageability of stimuli.
Methods: 32 healthy controls were compared with 30 schizophrenia
patients and 28 patients with bipolar mania. They were adminis-
tered a computerised lexical decision task that required them to
distinguish words from pseudo-words. Reaction time and accuracy
was recorded.
Results: Both patient groups showed reduced overall performance
on the task, that is, reduced accuracy and increased response times
in deciding whether words and pseudo-words were real words.
Patient’s poor performance was exaggerated for low frequency word
stimuli. There were no diﬀerences across the two patient groups.
Conclusions: This is the first known investigation comparing word
recognition in bipolar and schizophrenia. The data suggest that
individuals with mania have deficits in lexical access that is compa-
rable to that found in SZ. Further investigation of the contribution
of word recognition deficits to performance on verbal learning and
memory tasks in these two cohorts is necessary.
P-283
Cognitive control predicts facial emotion
recognition and functioning in euthymic bipolar
patients
V Santosa,b, S Caldeiraa,c, N Madeiraa,b, MJ Martinsb,c, M Bajoucoa,b,
C Roquea,b, D Motaa,b, A Oliveiraa,b, J Ribeiroa, AT Pereirab,
A Macedoa,b
aDepartment of Psychiatry, Coimbra Hospital and University
Center, Coimbra, Portugal, bDepartment of Psychological Medicine,
Faculty of Medicine- University of Coimbra, Coimbra, Portugal,
cFaculty of Psychology and Educational Sciences- University of
Coimbra, CINEICC - Cognitive-Behavioral Center for Research and
Intervention, Coimbra, Portugal
Background and Aims: In Bipolar Disorder there is often a gap
between functional recovery and symptomatic remission after a
mood episode. Executive control and social cognition deficits can
putatively account for the psychosocial impairment in euthymia.
The aim of this study was to explore the relationships between cog-
nitive control, emotional processing and functioning in euthymic
bipolar patients.
Methods: Fifty Bipolar Disorder patients, fulfilling euthymia crite-
ria, were assessed cross-sectionally for executive functions (WCST,
Stroop, TMT-B), facial aﬀect recognition and psychosocial func-
tioning (FAST). The neuropsychological performance was com-
pared with a control sample (n = 50). Multivariate regression and
mediation models (Preacher and Hayes bootstrapping methodol-
ogy) were performed in the clinical sample.
Results: Euthymic bipolar patients had a worst performance than
controls in all executive tasks (all p < 0.01) and in the emotion pro-
cessing test (p = 0.004). WCST categories (b = 0.347; p = 0.014;
partial = 0.348) and Stroop (b = 0.325; p = 0.021; partial = 0.328)
were significant predictors of emotional processing (Adjusted
R2 = 0.309, p < 0.001). WCST categories (b= !0.373; p = 0.007;
partial = !0.380) and Stroop (b = !0.339; p = 0.013; par-
tial = !0.351) were also significant predictors of functioning
(Adjusted R2 = 0.351, p < 0.001). In mediational analysis, inhibi-
tory control was found to be a partial mediator of the relationship
between category formation and functioning (Indirect
Eﬀect = !1.268; BCA 95% CI: !2.599–!0.218) and category for-
mation and facial emotion recognition (Indirect Eﬀect = 0.327;
BCA 95% CI: 0.080 - 0.715).
Conclusions: Our results are in agreement with other studies that
explore the relations between neurocognition and functionality
and adds data about the association between non-social and social
cognition domains, in need of further exploration in future studies.
Emotional processing was not an independent predictor of psy-
chosocial functioning.
P-284
The impact of emotional reactivity on executive
functioning and its association with hypomanic
personality
V Scholz, B Kollmann, J Linke, S Sch€onfelder, M Wessa
Department of Psychology Faculty of Clinical Psychology and
Neuropsychology, University Mainz, Mainz, Germany
Background and Aims: Patients with bipolar disorder (BD) display
varying degrees of neurocognitive impairment even during euthy-
mia, with current mood impacting neurocognitive functioning. It
remains largely unknown, which processes influence these state-
specific disruptions. A self-report measure (MATHYS) by Henry
et al. (2008) explores global activation (GA) and emotional reactiv-
ity (ER) and distinguishes BD-related mood states. Our goal was
to investigate the impact of current GA and ER on executive func-
tioning in euthymic BD patients and the association with traits
linked to elevated risk for BD.
Methods:We investigated euthymic BD-I patients and healthy con-
trols (HC). HC and BD-I did not diﬀer significantly in age and gen-
der ratio. The GA and ER scores were compared with an analysis
of covariance. Spearman correlation coeﬃcients were calculated
for test scores of executive functions, often impaired in BD, and
for a previously established risk factor for BD, namely hypomanic
personality.
Results: BD-I patients showed significantly higher ER than HC,
but no diﬀerences in GA levels. ER correlated negatively with
© 2016 The Authors
Bipolar Disorders © 2016 John Wiley & Sons A/S, Bipolar Disorders, 18 (Suppl. S1) 70–194158
18th Annual ISBD & 8th Biennial ISAD


Cognitive control predicts facial emotion recognition and functioning in euthymic bipolar patients

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Cognitive control predicts facial emotion recognition and functioning in euthymic bipolar patients

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