Carbon dioxide (CO2) is an appropriate replacement for conventional refrigerants due to its low global warming effects. However, its application within a traditional refrigeration compression cycle leads to low thermodynamic performance due to the large expansion losses in a throttling process. The application of ejectors allows reducing these losses. Many scenarios of ejector-based cycles have been proposed. Among them four different configurations may be distinguished: an expansion work recovery cycle (EERC), a liquid recirculation cycle (LRC), an increasing compressor discharge pressure cycle (CDPC) and a vapor jet refrigeration cycle (VJRC). This study deals with the comparative analysis of these cycles. In order to study the performance of the cycles, the numerical simulations are developed using EES software. Two performance criteria, energy efficiency (COP) and exergy efficiency are evaluated for each cycle. The highest values of these criteria point to the most thermodynamically efficient cycle. The results show that the EERC has the highest COP and exergy efficiency compared to other cycles. For example, the COP of the EERC is 3.618 and the exergy efficiency is 9.68%. The COP (resp. exergy efficiency) is approximately 23.3% (resp. 23.3%), 24.9% (resp. 25.5%) and 5.6 times (resp. 56.2%) higher than the corresponding energy and exergy efficiencies of LRC, CDPC and VJRC. Moreover, in comparison with a basic throttling valve cycle, the COP and exergy efficiency in EERC are higher up to 23% and 24% correspondingly. The detailed exergy analysis of EERC cycle has pinpointed the equipment where the major exergy losses take place. The largest losses occur in the evaporator (about 33% of the total exergy destruction of the cycle) followed by the compressor (25.5%) and the ejector (24.4%).This project is a part of the Collaborative Research and Development (CRD) Grants Program at ‘Université de Sherbrooke’. The authors acknowledge the support of the Natural Sciences and Engineering Research Council of Canada, Hydro-Québec, Rio Tinto, Alcan and Canmet ENERGY Research Center of Natural Resources Canada