<p><b>A.</b> vTK+FVB/N mice that did not receive GCV showed normal liver histology. <b>B–C.</b> vTK+FVB/N mice that received 50 mg/kg GCV showed increased cytoplasmic and nuclear enlargement with increased acidophilic bodies (B, arrowhead), apoptotic bodies (B, arrow), and areas of confluent necrosis (C, arrows) (A–C:Hematoxylin and eosin, original magnification ×200). <b>D.</b> TUNEL immunostaining showing increased apoptotic nuclei (arrows) in livers post GCV (Immunoperoxidase, original magnification ×200).</p
