<p>A) Outline of a minimal mitotic cell cycle model <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0008201#pone.0008201-Goldbeter1" target="_blank">[29]</a>, based on a cascade of post-translational modifications that modulates in the end a protease degrading a cyclin. Such a negative feedback loop generates oscillations. B) The blue curve is the periodic variation of cyclin with the set of parameters of Goldbeter (1991). The green curve (with faster cycling) corresponds to parameters for doubled enzyme concentrations resulting from a WGD followed by extensive DNA deletions.</p
