Dynamics of the formation of the dimer MM (in balance with monomer N) and genome duplication.

Abstract

<p>Formation of MM depends on the synthesis rate S, the degradation of the coding mRNA and monomers (D) and the interaction of the monomers. Blue curve: dimer formation after WGD (parameters S = D = 1) and red curve dimerization after WGD+deletions (leaving only M, N and the protease-encoding genes as duplicates, S = D = 2). Notice that the steady state is reached more rapidly in the latter system (red curve) than in the orginal tetraploid or diploid (blue curve). Such a kinetic difference can be crucial, especially especially if time delays (as in the mitotic clock of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0008201#pone-0008201-g003" target="_blank">figure 3</a>) are important. If MM is in balance with monomers N, there might be a problem before reaching the steady state.</p

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