<p>A: Simulation results based on Eq. (1) with and the source term Eq. (5) for different substitution therapies in the absence of fluctuations (). The frequencies of the substitution therapies are: (black line), (red line), (green line), and (blue line). B: Analytical calculation of the relative difference in the IgG doses per treatment (red line) and time-integrated (green line) for different substitution therapies according to Eqs. (59) and (60), respectively. C: Analytical calculation of the serum IgG peak level (red line) and the time-averaged dose (green line) for different substitution therapies according to Eqs. (61) and (62), respectively. D: The same as in A but in the presence of fluctuations in the administered IgG amount per treatment with fluctuation strength .</p
