Simulation results of immune responses to infections for different clearance rates in the presence of fluctuations in the administered IgG dose per treatment with fluctuation strength .
<p>The serum IgG concentration and the bacteria population are plotted as function of time and for substitution therapies with frequencies (black line) and (blue line). A and B: For clearance rate the infection is cleared after 43 days under substitution therapy with frequency , whereas a chronic infection develops under substitution therapy with frequency . C and D: For clearance rate the infection is cleared within 1 and 3 days under substitution therapy with frequency and , respectively. E and F: For the same parameters as in C and D but for a different random realization of fluctuations in the administered IgG dose per treatment. Even though the infection is ultimately cleared, this is only achieved after 44 days under substitution therapy with frequency .</p
