Virus Titers in Lungs of BALB/c Mice Inoculated with SARS-CoV or MA15 Virus

Abstract

<p>Data represents a compilation of two experiments. In each experiment, groups of four mice were inoculated intranasally with 50 μL of SARS-CoV (Urbani) (10^5.0 TCID₅₀/mouse, black bars) or MA15 virus at lethal (10^5.6 TCID₅₀/mouse, white bars) or sub-lethal (10^3.6 TCID₅₀/mouse, light gray bars) doses. Mice were sacrificed on indicated d.p.i. Mice receiving lethal doses of MA15 virus did not survive beyond day 4. Bars represent mean viral titers; error bars indicate standard error. Asterisks indicate significant differences (<i>p</i> < 0.05) compared with titers in mice receiving lethal doses of MA15 virus. Dotted line indicates lower limit of detection (10^1.5 TCID₅₀/g).</p